器官发育和程序性细胞死亡中的基因调控_2002年诺贝尔生理学和医学奖工作...
2002年诺贝尔奖介绍
器官发育和程序性细胞死亡中的基因调控
2002年诺贝尔生理学和医学奖工作介绍
何 杰 韩佩韦 陈 畅**
(中国科学院生物物理研究所，北京
100101)
970 生物化学与生物物理进展  Prog.Biochem.Biophys.    2002;29(6)
971 2002;29(6)生物化学与生物物理进展Prog.Biochem.Biophys.
Genetic Regulation of Organ Development and Programmed Cell Death
HE Jie,HAN Pei-Wei,CHEN Chang *
(I nstitute of Biophysics,The Chinese A cad emy of S ciences,Beij ing 100101,China )
Abstract  Three scientists w ere aw arded the 2002Nobel Prize in Physiology of Medicine for discoveries concerning the genetic reg ulation of organ development and prog rammed cell death.T he laureates have established the nematode Caenor habditis elegans as an experimental model,m apped the invariant cell lineage,identified key g enes reg ulating org an development and program med cell death and show n that corresponding g enes exist in higher species,including man.These discoveries are of prim ary importance for understanding the pathogensis of various of human diseases.
诺贝尔奖 中国
Key words  nematode Caenorhabditis elegans ,cell lineage,prog rammed cell death
*Corresponding author.T el:86 10 64888406,E  mail:changchen@moon.ibp.ac
Received:November 8,2002  Accepted:November 25,2002 972 生物化学与生物物理进展  Prog.Biochem.Biophys.    2002;29(6)

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