2,3-DIHYDRO-1H-ISOINDOLE DERIVATIVES USEFUL AS MOD
专利名称：2,3-DIHYDRO-1H-ISOINDOLE DERIVATIVES USEFUL AS MODULATORS OF DOPAMINE
D3 RECEPTORS (ANTIPSYCHOTIC AGENTS)发明人：JOHNSON, Christopher, N.-SmithKline
Beecham Pharm.,STEMP, Geoffrey-
SmithKline Beecham Pharmaceuticals
申请号：EP99953832.5
申请日：19991006
公开号：EP1119562A1
公开日：
模拟人生3mod怎么用
20010801
专利内容由知识产权出版社提供
摘要：0ompounds of formula (I), wherein R2 represents a hydrogen atom or a C¿1-4? alkyl group; q is 1 or 2; A represents a group of formula (a), (b), (c) or (d), wherein Ar represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; or an optionally substituted bicyclic ring system; Ar?1 and Ar2¿ each independently represent an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; and Y represents a bond, -NHCO-, -CONH-, -CH¿2?-, or -(CH2)mY?1(CH¿2)n-, wherein Y1 represents O, S, SO¿2? or CO and m and n each represent zero or (I) such that the sum of m + n is zero or 1; providing that when A represents a group of formula (a), any substituent present in Ar ortho to the carboxamide moiety is necessarily a hydrogen or methoxy group; r and s independently represent an integer from zero to 3 such that the sum of r and s is equal to an integer from 1 to 4; V represents a bond, O or S; and salts thereof.Compounds of formula (I) and their salts have affinity for dopamine receptors, in particular the D3
receptor, and thus potential in the treatment of conditions wherein modulation of the D3 receptor is beneficial, e.g. as antipsychotic agents.
申请人：SMITHKLINE BEECHAM PLC
地址：New Horizons Court Brentford,Middlesex TW8 9EP GB
国籍：GB
代理机构：Waters, David Martin
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